Berrchem API introductions

The in-house development and production of various multi-customer active pharmaceutical ingredients is one pillar of BerrChem's API business model. A product list of currently offered generic APIs is available and information about new products under the development and/or evaluation can be provided upon request.

From simple, single-step reactions to more complex, difficult multi-step reactions and everything in between, BerrChem can handle your individual requirements for the good cooperation with the top chemical scientists in China. We offer starting materials, intermediates, reference compounds, and derivatives of lead compounds in scales ranging from grams to hundreds of kilograms and tons.For Example:

5,5-Dimethylthiazolidine-4-carboxylic acid (I) is protected as the N-Boc derivative (II), and subsequently treated with allyl bromide (III) and triethylamine to form the allyl ester (IV). Acidic Boc group cleavage in (IV) provides amino ester (V), which is further coupled to the lactone acid (VI) to furnish amide (VII). The allyl ester group of (VII) is then removed by treatment with morpholine and Pd(PPh3)4, yielding acid (VIII). This is then coupled to (3,5-dimethylisothiazol-4-yl)methyl amine (IX) employing EDC/HOAt to afford the corresponding amide (X). Lactone ring opening in (X) by hydrolysis with LiOH gives rise to the hydroxy acid (XI), which is further protected as the silyl ether (XII) employing t-butyldimethylsilyl triflate.