3-Hydroxyphenylacetic acid [621-37-4]

3-Hydroxyphenylacetic acid

CAS Number 621-37-4 Beilstein Registry Number 2086506 EC Number 210-684-4 MDL number MFCD00004337
Chemical Name 3-Hydroxyphenylacetic acid
assay ≥98%
mp 129-133 °C(lit.)
Stock Quantity 100kg

Related Product Information
2. Impact of short-term intake of red wine and grape polyphenol extract on the human metabolome.
Doris M Jacobs et. al
Journal of agricultural and food chemistry, 60(60), undefined (2012-3-1)
Red wine and grape polyphenols are considered to promote cardiovascular health and are involved in multiple biological functions. Their overall impact on the human metabolome is not known. Therefore, exogenous and endogenous metabolic effects were de…Read More
3. Chlorogenic acid, quercetin-3-rutinoside and black tea phenols are extensively metabolized in humans.
Margreet R Olthof et. al
The Journal of nutrition, 133(133), undefined (2003-5-29)
Dietary phenols are antioxidants, and their consumption might contribute to the prevention of cardiovascular disease. Coffee and tea are major dietary sources of phenols. Dietary phenols are metabolized extensively in the body. Lack of quantitative d…Read More
4. Supplementation with grape seed polyphenols results in increased urinary excretion of 3-hydroxyphenylpropionic Acid, an important metabolite of proanthocyanidins in humans.
Natalie C Ward et. al
Journal of agricultural and food chemistry, 52(52), undefined (2004-8-19)
Grape seed extract provides a concentrated source of polyphenols, most of which are proanthocyanidins. Polymeric proanthocyanidins are poorly absorbed in the small intestine of humans, and exposure may result from metabolism to phenolic acids by colo…Read More
5. Human fecal water inhibits COX-2 in colonic HT-29 cells: role of phenolic compounds.
Pernilla C Karlsson et. al
The Journal of nutrition, 135(135), undefined (2005-9-24)
The inducible enzyme cyclooxygenase-2 (COX-2) plays a major role in the regulation of inflammation and possibly in the development of colon cancer. The aim of the present study was to screen for COX-2 inhibitors in samples of fecal water (the aqueous…Read More
6. A metabolite profiling approach to identify biomarkers of flavonoid intake in humans.
Wai Mun Loke et. al
The Journal of nutrition, 139(139), undefined (2009-10-9)
Flavonoids are phytochemicals that are widespread in the human diet. Despite limitations in their bioavailability, experimental and epidemiological data suggest health benefits of flavonoid consumption. Valid biomarkers of flavonoid intake may be use…Read More
7. An exploratory NMR nutri-metabonomic investigation reveals dimethyl sulfone as a dietary biomarker for onion intake.
Hanne Winning et. al
The Analyst, 134(134), undefined (2009-10-20)
The metabolome following intake of onion by-products is evaluated. Thirty-two rats were fed a diet containing an onion by-product or one of the two derived onion by-product fractions: an ethanol extract and the residue. A 24 hour urine sample was ana…Read More
8. Targeted metabolic profiling of phenolics in urine and plasma after regular consumption of cocoa by liquid chromatography-tandem mass spectrometry.
Mireia Urpi-Sarda et. al
Journal of chromatography. A, 1216(1216), undefined (2009-8-13)
The biological properties of cocoa (Theobroma cacao L.) polyphenols are strictly dependent on their bioavailability. A long-term cocoa feeding trial was performed with subjects at high risk for cardiovascular disease. Subjects (n=42) received two sac…Read More
9. Effect of milk on the urinary excretion of microbial phenolic acids after cocoa powder consumption in humans.
Mireia Urpi-Sarda et. al
Journal of agricultural and food chemistry, 58(58), undefined (2010-3-13)
Health effects of cocoa flavonols depend on their bioavailability, which is strongly influenced by the food matrix and the degree of flavanol polymerization. The effect of milk on the bioavailability of cocoa flavanoids considering phase II metabolit…Read More
10. Precursors and metabolites of phenylethylamine, m and p-tyramine and tryptamine in human lumbar and cisternal cerebrospinal fluid.
S N Young et. al
Journal of neurology, neurosurgery, and psychiatry, 45(45), undefined (1982-7-1)
Phenylacetic acid, p-hydroxyphenylacetic acid, m-hydroxyphenylacetic acid, phenylalanine, indoleacetic acid, 5-hydroxyindoleacetic acid and tryptophan were measured in lumbar and cisternal cerebrospinal fluid (CSF) taken during pneumoencephalography….Read More
11. Epicatechin, procyanidins, and phenolic microbial metabolites after cocoa intake in humans and rats.
Mireia Urpi-Sarda et. al
Analytical and bioanalytical chemistry, 394(394), undefined (2009-4-1)
Proanthocyanidins, flavonoids exhibiting cardiovascular protection, constitute a major fraction of the flavonoid ingested in the human diet. Although they are poorly absorbed, they are metabolized by the intestinal microbiota into various phenolic ac…Read More
12. The effects of beta-phenylethylamine on tyramine and dopamine metabolism.
P S McQuade and P L Wood
Progress in neuro-psychopharmacology & biological psychiatry, 7(7), undefined (1983-1-1)
The administration of deuterated beta-phenylethylamine to mice causes increased concentrations of deuterated para-hydroxyphenylacetic acid and meta-hydroxyphenylacetic acid within the caudate nuclei two hours after injection. Deuterated m-HPAA concen…Read More

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4-Indolyl acetate [5585-96-6]

4-Indolyl acetate

CAS No. information 5585-96-6
Name Details: 1H-Indol-4-yl acetate
chemical name:4-Indolyl acetate
assay 98%
mp 100-102 °C(lit.)
Stock Information: Stock

Empirical Formula (Hill Notation) C10H9NO2 Molecular Weight 175.18 MDL number MFCD00010678
4-Indolyl acetate has been employed as standard in a protocol for the optimization of gradient reversed phase chromatographic peak capacity for separation of small molecules[1].
Reactant for preparation of:
• Inhibitors of HIV-1 attachment
• Prostanoid EP3 receptor antagonist, as a novel antiplatelet agent
• Indolyl-nitroalkanes via N-bromosuccinimide catalyzed synthesis
• Psilocybin as a medicinal agent
Optimization of gradient reversed phase chromatographic peak capacity for low molecular weight solutes.
Arianne Soliven et. al
Journal of chromatography. A, 1273(1273), undefined (2012-12-25)
A general protocol for optimizing peak capacity for the separation of low molecular weight molecules under gradient elution conditions has not yet been developed. By studying the effects of gradient time, flow rate, temperature, final eluent composit.

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(R)-(-)-Benzyl glycidyl ether [14618-80-5]

(R)-(-)-Benzyl glycidyl ether

CAS No. information 14618-80-5
Name Details (R)-(-)-Benzyl glycidyl ether
assay 99%
optical activity [α]20/D −5.4°, c = 5 in toluene
refractive index n20/D 1.517(lit.)
density 1.077 g/mL at 25 °C(lit.)
storage temp. 2-8°C

Beilstein Registry Number 3588399 MDL number MFCD00068409 PubChem Substance ID 24862201
Used in the preparation of the lactone fragment of compactin and mevinolin.[1] Chiron in the preparation of syn-1,3-polyols,[2] dideoxynucleosides,[3] and a spiroacetal cyanohydrin
1. Akira Fujiki Synthesis , 539-539, (1989)
2. Bijan Ahvazi The Journal of Organic Chemistry 53, 4495-4495, (1988)
3. 1′,2′-seco-dideoxynucleosides as potential anti-HIV agents.
E Abushanab and M S Sarma
Journal of medicinal chemistry, 32(32), undefined (1989-1-1)
1′,2′-seco-2′,3′-Dideoxycytidine (12), -guanosine (14), -adenosine (16), and -inosine (18) were prepared from (R)-benzylglycidol as potential anti-HIV agents. When compared to ddAdo in protecting ATH8 cells, they were found to be inactive.
4. Pierre Vantourout Journal of the Chemical Society. Chemical Communications , 291-291, (1993)

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Piperidine-4-carboxamide [39546-32-2]

CAS No. information 39546-32-2
Name Details Piperidine-4-carboxamide
Molecular Formula C6H12N2O
Formula Weight 128.172
Stock Info Stock
Purity 98+% purity limited
mp 145-148 °C(lit.)
Available Spectra NMR,HPLC or GC,COA
Size Up to Kgs quantity
Shipping Regulated for Shipping

EC Number 254-501-6 MDL number MFCD00038012 PubChem Substance ID 24895948
Reactant for synthesis of:
• Survival motor neuron (SMN) protein modulators
• Diaminotriazine hNav1.7 inhibitors
• Heteroalicyclic carboxamidines as inhibitors of inducible nitric oxide synthase
• Orally available naphthyridine protein kinase D inhibitors
• Phosphodiesterase 5 inhibitors

Reactant for identification of small molecular inhibitors of importin-β mediated nublear import

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CAS 7779-75-1 Isobutyl 3-oxobutanoate

CAS No. information 7779-75-1
Name Details Isobutyl 3-oxobutanoate
assay ≥98.0% (GC)
refractive index n20/D 1.424(lit.)
n20/D 1.424
bp 100 °C/22 mmHg(lit.)
density 0.98 g/mL at 25 °C(lit.)
Available Spectra NMR,HPLC or GC,COA,MSDS ECT
Size Up to Kgs quantity
Shipping Regulated for Shipping

EINECS 231-937-5 MDL number MFCD00059349 PubChem Substance ID 24845044

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5-Bromo-2-pyridinecarbonitrile CAS 97483-77-7

Chemical Name: 5-Bromo-2-pyridinecarbonitrile
Molecular Formula: C6H3BrN2
Formula Weight: 183.01
CAS No.: 97483-77-7

5-Bromo-2-pyridinecarbonitrile(97483-77-7) Related Product Information
5-BROMO-6-METHOXYPYRIDINE-2-CARBONITRILE 5-BROMO-2-CYANONICOTINIC ACID 6-AMINO-5-BROMO-3-CHLOROPYRIDINE-2-CARBONITRILE 5-BROMO-3-FLUORO-PYRIDINE-2-CARBONITRILE 6-AMINO-5-BROMO-3-FLUOROPYRIDINE-2-CARBONITRILE 3-AMINO-5-BROMO-6-METHOXYPYRIDINE-2-CARBONITRILE 5-Bromo-2-pyridinecarbonitrile Sodium cyanoborohydride CYANOPYRIDINE Bromine ETHYL 2-CYANOACRYLATE 3-Bromoanisole 4-Cyanopyridine 1-Hexadecylpyridinium bromide 3-Cyanopyridine 2-Hydroxypyridine 2-Cyanopyridine 2,6-Lutidine

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Molecular Formula: C5H5BrN2
Formula Weight: 173.0106
CAS No.: 7752-78-5

Synonyms:5-BROMO-2-METHYL-PYRIMIDINE;5-bromo-2-methyl-pyrimidi…;PyriMidine, 5-broMo-2-Methyl-;5-Bromo-2-methyl-1,3-diazine;2-methyl-5-bromo-1,3-pyrimidine

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tert-Butyl 1-piperazinecarboxylate CAS 57260-71-6

CatNumber: BR49934
Chemical Name: tert-Butyl 1-piperazinecarboxylate
Formula: C9H18N2O2
Formula Weight: 186.25
CAS No.: 57260-71-6

Preparation Products 4-(2-FORMYLPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER–>1-(CYCLOPROPYLMETHYL)PIPERAZINE–>1-(2-Methoxyethyl)piperazine–>N-Boc-4-(Cyclopropylmethyl)piperazine–>1-BOC-4-(4-FORMYLPHENYL)PIPERAZINE–>1-(2-PYRAZINYL)-PIPERAZINE–>tert-Butyl 4-[4-(trifluoromethyl)pyrimidin-2-yl]piperazine-1-carboxylate ,97%–>TERT-BUTYL 4-(5-FORMYLPYRID-2-YL)PIPERAZINE-1-CARBOXYLATE–>PIPERAZINE-1,4-DICARBOXYLIC ACID TERT-BUTYL ESTER METHYL ESTER

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CAS 20439-47-8 (1R,2R)-(-)-1,2-Diaminocyclohexane

Product (1R.2R)-(-)-1.2-Diaminocyclohexaneb
Batch No BR49548
CAS 20439-47-8
Formula C6H14N2
Weight 114.19


Product Categories: chiral;API intermediates;Chiral reagent;Amines (Chiral);Chiral Building Blocks;Synthetic Organic Chemistry;CHIRAL CHEMICALS;Chiral Compound;Cycloalkanes;organic amine;Amines;Miscellaneous Reagents
Chemical Properties white to light yellow crystal powder
Usage Can be used as a building block for chiral ligands.
Usage suzuki reaction

1. Mukaiyama, T. Aldrichimica Acta 29, 59, (1996)

2. Chenier, P.J. et al. Tetrahedron Lett. 38, 7341, (1997)

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171178-33-9 6-chloropyrido[3,2-d]pyrimidin-4(3H)-one

Product information 171178-33-9
Batch No 11792 US2012/238587 A1; US 20120238587 A1
Product details 6-Chloropyrido[3,2-d]pyrimidin-4(3H)-one
Molecular Formula C7H4ClN3O
Formula Weight 181.579
Stock Info New update products
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