New API pharma lurasidone 367514-87-2

Now, BerrChem can offer API of Iurasidone.

  • Product Name: lurasidone
  • Synonyms: lurasidone;(3aR,4S,7R,7aS)-2-[[(1R,2R)-2-[[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]methyl]cyclohexyl]methyl]hexahydro-4,7-methano-1H-isoindole-1,3(2H)-dione;
  • CAS: 367514-87-2
  • Structure:
  • InChI: InChI=1/C28H36N4O2S/c33-27-24-18-9-10-19(15-18)25(24)28(34)32(27)17-21-6-2-1-5-20(21)16-30-11-13-31(14-12-30)26-22-7-3-4-8-23(22)35-29-26/h3-4,7-8,18-21,24-25H,1-2,5-6,9-17H2/t18-,19+,20-,21-,24+,25-/m0/s1
  • Product Purchase sales@berrchem.com

The large scale synthesis of lurasidone began with the bis-mesylation of commercially available diol 1 to furnish disulfone 2 Dialkylation of piperazine 3 with disulfone 2 under basic conditions afforded spirocyclic tetralkyl ammonium species 4. By subjecting tetralkyl ammonium salt 4 to basic conditions in the presence of succinimide 5 an interesting regioselective ring-opening alkylation reaction occurs to form the 1,2-trans-substituted cyclohexane motif of lurasidone. Finally, exposure of lurasidone to hydrochloric acid provided the lurasidone hydrochloride salt

  1. ^ JP 2006282527, YAGI HIDEKI; KODERA TAKAHIRO; KURUMAYA MASAHIKO; TANAKA KAZUYUKI, “CYCLOHEXANE DERIVATIVE AND METHOD FOR PRODUCING THE SAME”, published 2006-10-19
  2. Jump up^ US patent 20110263847, Ae Nobuyuki and Fujiwara Yuji, “Process of a Quaternary Ammonium Salt”, issued 2011-10-27
  3. Jump up^ WO 2005009999, KAKIYA YUZO; ODA MAYUMI, “PROCESS FOR PRODUCING IMIDE COMPOUND”, published 2005-02-03
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