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Complex Chemicals Manufacturing

From the First Idea to the Finished Product, we help our customers to manage costs, reduce infrastructure investment and compress time-to-market by providing integrated contract development and manufacturing services.

Complex and Multi-Step Synthesis

BerrChem excels in complex and challenging custom synthesis, specializing in carbohydrate and nucleoside chemistry. We solve the problems others cannot.We have been helping our customers innovate by taking on the most complex challenges in organic chemical synthesis and producing custom molecules for novel products and projects. BerrChem works in partnership to deliver high quality materials and methods to take you and your organization forward. As part of our suite of end-to-end CDMO services, we offer custom synthesis as a stand-alone project or as part of a longer program towards large-scale or c-GMP manufacture.
Our skilled custom synthesis teams can start from your first ideas, route scouting and developing a synthesis method, or we can use or improve upon an existing synthesis route as required. We welcome projects involving challenging multi-step synthesis and are committed to innovating our internal processes to enable syntheses of complex compounds. With support from our first-class analytical development and QC teams, we can provide the material you want at the quality you need.

Functional chemistry experts

Functionalized carbohydrate building blocks and derivatives
Oligosaccharide synthesis
Nucleosides, dinucleotides and analogues
Heterocyclic chemistry
Fluorination, phosphorylation and sulphation chemistry
Novel enzyme substrates
Natural product synthesis
Impurities and metabolites
Protein conjugation, biotin and click linkers
Biocatalysis

Operational areas of excellence

High purity complex products
Synthetic route development
Medicinal chemistry
Regulated materials

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CAS# 162012-69-3

7-Fluoro-6-nitro-4-hydroxyquinazoline

7-fluoro-6-nitroquinazolin-4-ol

Purchase orders

Purchase orders may be placed by fax, e-mail, telephone or regular mail. Please indicate the name, product number, quantity, and packaging size on your purchase order. You must state any special conditions that are on your confirming purchase order when you first place your order with BerrChem Company. Please mark confirming purchase orders clearly to prevent duplication.

Aliphatic Chain Compounds

Aliphatic chain compounds include aliphatic compounds and chain compounds containing other elements or groups. Aliphatic hydrocarbons are hydrocarbons with the basic properties of aliphatic compounds. In aliphatic compounds, carbon atoms are arranged in straight chain, branched chain or cyclic, which are respectively called straight chain aliphatic hydrocarbons, branched chain aliphatic hydrocarbons and alicyclic hydrocarbons. Some cyclic hydrocarbons are different in nature from aromatic hydrocarbons, and are very similar to aliphatic hydrocarbons. Such cyclic hydrocarbons are called alicyclic hydrocarbons. In this way, aliphatic hydrocarbons become a general term for all hydrocarbons except aromatic hydrocarbons. Aliphatic hydrocarbons and their derivatives (including halogenated hydrocarbons) and alicyclic hydrocarbons and their derivatives are collectively referred to as aliphatic compounds.

Borates Boronic Acids and Esters

Borates are classified as critical materials, they are the main source of boron and have a variety of industrial applications. Organic trifluoroborate is stable to heat, air and humidity, and is a very convenient crystalline boric acid compound. Since it has a tetra-coordinated boronic acid structure after the substitution of fluorine, it does not exhibit Lewis acidity and is stable to oxidation conditions. In addition, it can be regarded as the protector of boronic acid and boronic acid ester, which can be converted into each other. The compound can generally exist stably in organic solvents, but will decompose in protic solvents to liberate trivalent boron, so it can be directly used as a substrate for Suzuki coupling. The difference between trifluoroborate and boric acid is that it must exist in a monomeric form, so the equivalent weight can be closely controlled.
Boronic acids and boronate esters are commonly used reagents in Suzuki–Miyaura coupling chemistry. Organoboron derivatives are common reagents for C–C bond formation, either through classical palladium-mediated transformations or through other newer coupling methods. Boronic esters and acids are potential intermediates in the manufacture of many active pharmaceutical ingredients (API). Bridged Compounds

Bridged Compounds

Bridged ring compound refers to any two rings in the compound, which share two non-directly connected carbon atoms, and are classified into bicyclic hydrocarbons, tricyclic hydrocarbons, tetracyclic hydrocarbons, etc. Carbon atoms used in two or more rings are bridgehead carbon atoms, and the bond connecting the bridgehead carbon atoms is called a bridge. Bridged ring compounds are a class of organic compounds that are widely present in nature and usually have important physiological activities, such as the famous anticancer drug paclitaxel and antimalarial drug artemisinin.

Catalysts and Ligands

A catalyst refers to a substance that increases the rate of a reaction without changing the overall standard Gibbs free energy change of the reaction. Ligands represent atoms, molecules, and ions that can bond with a central atom (metal or metalloid). In general, ligands will donate at least one electron when participating in a bond. Two-phase catalysis of catalysts and ligands is the first application in the field of fluorine chemistry. The method of self-fluorine two-phase catalysis has developed rapidly, and a large number of new fluorine-based catalysts and ligands (especially phosphines) have been obtained in the field of chemistry.

Fluorinated Compounds

Fluorine is the most electronegative element in the periodic table, and the fluorine atom has a small atomic radius, so fluorine-containing organic compounds have many wonderful properties. For example, the introduction of fluorine atoms or fluorine-containing groups into drug molecules can improve the permeability to cell membranes, metabolic stability and bioavailability; in addition, the introduction of fluorine atoms will improve the lipid solubility of the compound and promote its absorption in the body. The speed of delivery changes the physiological effect. In the field of medicinal chemistry, the introduction of fluorine atoms into organic molecules is an important direction for the development of new anticancer drugs, antitumor drugs, antiviral agents, anti-inflammatory drugs, and central nervous system drugs.

Natural Products

We offers over 2,000 natural products and specializes in supplying phytochemicals (notably flavonoids) and other types of naturally derived compounds such as chalcones, alkaloids, caffeoylquinic acids, coumarins, terpenes and steroids. Our high purity natural products are used for research, development, regulatory and testing purposes in fields such as biology, metabolomics, agronomy, crop protection, nutrition, nutraceuticals, food and feed, flavour and fragrance, cosmetics, healthcare and pharmaceuticals.

Alkaloids Anthocyanidins Chalcones Coumarins
Flavonoids Iridoids Kavalactones Lignans
Limonoids Organosulfur compounds

Spiro Compounds

A spiro compound is a polycyclic compound in which two monocyclic rings share one carbon atom; the shared carbon atom is called a spiro atom. Spiro compounds have rigid structures, stable structures, and have special properties that general organic compounds do not possess, such as anomeric effect, spiro conjugation and spiro hyperconjugation. Compared with the monocyclic structure or the planar aromatic structure, the spiro structure has a larger three-dimensional structure; the heterocyclic spiro structure is also regarded as the biological isostere of some groups, which can change the drug to a certain extent. The water solubility, lipophilicity, dominant conformation and ADMET properties of the molecule make the optimized lead molecule easier to drug. Therefore, spiro compounds occupy a very important position in drug development.

Carbohydrates

Discover our extensive and comprehensive range of carbohydrates for scientists within the life sciences and chemistry research fields. Our carbohydrate products include: monosaccharide building blocks, functionalised sugars (including fluoro, azido, amino and lactone derivatives), glucuronides, oligosaccharide reference compounds (both natural and synthetic), polysaccharides and sugar-based detergents. Within our carbohydrate product range, we offer tools for glycobiology, chemo-enzymatic glycosylation, glycan assembly and protein glycosylation modification.

Monosaccharides Polysaccharides Oligosaccharides
Detergents GalNAc Cluster Derivatives Cyclodextrins